808R Spring 2026 DNA's Secret Life: Jumping Genes are Rewriting our Genetic History

Over 40% of our DNA is made up of "jumping genes,” or parts of our DNA that can copy and insert themselves into new locations within our genes. Known scientifically as transposons, these elements were acquired by our ancient ancestors over millions of years. Though nearly all are now silent, a tiny fraction, less than 0.05%, remains active. We explore how these once mobile DNA pieces have influenced human biology. We will learn: 1) What jumping genes are, when did they enter our DNA, and how do they jump around? 2) What conditions reawaken these silent DNA pieces? 3) They are critically needed in early human development (e.g. placental function), but can cause problems with aging and chronic diseases. 4) New research tells us that we may be able to turn off harmful jumping gene activity or even use them to our advantage. This course is for anyone curious about the fact that 98% of our DNA is not genes, yet controls the keys to understanding health, disease and human evolution.

Suresh Mohla, PhD and endocrinologist, spent seven years at the University of Chicago, Pritzker School of Medicine. He has over 45 years of experience in cancer research including 25 years at the National Cancer Institute. Since 2020, he has taught at OLLI on topics in cancer, aging, and chronic diseases.